Arizona Cardinals vs San Francisco 49ers

Sun, Sep 21, 2025 | 4:25P EST
NFL WEEK 3
Point Spread Game
Arizona Cardinals
San Francisco 49ers
Team Total Game
Arizona Cardinals
San Francisco 49ers
Odds Format

Arizona Cardinals vs San Francisco 49ers Odds and Betting Lines

This is a testy NFC West game. It is one thing for Mac Jones to beat the New Orleans Saints. It will be another to top the Arizona Cardinals.

Arizona got off to a huge lead against Carolina in Week 2 and somehow had to hang on for dear life. Not a good look for Jonathan Gannon’s team.

The NFL odds have the home team, the 49ers, giving a point to Arizona. This feels like a tight game where points will be at a premium.

The NFL Week 3 betting odds have the total at 44 points. Look for it to go under in a divisional clash.

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  • only allowed on straight bets, Parlays and Teasers.
  • not available with Free Plays or Futures and Props
  • only available if you have pre existing, non graded wagers
  • you can only use the funds from the amount of the pre existing wager

How to Place a Rolling If Bet:

  • Choose any straight, parlay or teaser and Place it on the Bet Slip
  • Click on the Rolling If Bet button next to the wager detail
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  • Fill in the amount and confirm your wager (the system will not allow you a higher amount than what is available)
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