NFL Week 12 (2025) — Key Matchups to Watch and Betting Angles
Thursday Night Football:
Buffalo Bills @ Houston Texans
Thu., Nov 20 — 8:15 p.m. ET (Prime Video)
- Opening NFL odds: Bills –3 on the point spread, –160 moneyline; Texans +140; over/under 47.
- Buffalo backers who fear a late back-door cover can buy the line to –2.5 or slide the Bills into a six-point teaser with another favorite.
- Houston supporters might grab the plus-price moneyline or tie Texans +3 to the over in a same-game parlay for a juicier payout.
- Look for “yardage ladder” props on Josh Allen and C.J. Stroud, plus anytime-TD markets on Stefon Diggs and Nico Collins.
Early Sunday Window:
New England Patriots @ Cincinnati Bengals
Sun., Nov 23 — 1:00 p.m. ET (CBS/Paramount+)
- Current NFL betting lines list Cincinnati –9.5 and –425 on the moneyline; total 42.5.
- Patriots believers can tease rookie Drake Maye up to +15.5 or sprinkle the +330 underdog ML for a high-risk payout.
- Bengals bettors who dislike laying big chalk might grab an alternate spread (–6.5) at a shorter price or anchor Cincy’s ML in a weekend round-robin.
- Expect player-prop heat on Joe Burrow passing TDs and Maye interception totals; the winner banks a crucial head-to-head tiebreaker.
Late Sunday Window:
Philadelphia Eagles @ Dallas Cowboys
Sun., Nov 23 — 4:25 p.m. ET (FOX)
- The NFL betting market makes Dallas a slim 1.5-point favorite with a –120 moneyline; total 52.
- Eagles backers can tease Philly up to +7.5 or chase the +100 ML, linking it to the over in a same-game parlay.
- Cowboys bettors might pivot to an alternate line (–4.5) at plus money or pair Dallas ML with a CeeDee Lamb anytime-TD for a combo wager.
- Live-bet hunters may try to hedge the total if the first few drives stall and the number dips into the high-40s.
Monday Night Football:
Carolina Panthers @ San Francisco 49ers
Mon., Nov 24 — 8:15 p.m. ET (ESPN)
- Opening NFL odds: 49ers –7 on the spread, –300 ML; Panthers +250; total 46.
- San Francisco supporters who hate the juice can jump to an alternate spread (–9.5) at plus odds or anchor the ML in a two-team teaser with the under.
- Panthers backers can grab +7 or tease Carolina up to +13, pairing the dog spread with the under for a bigger payout.
- Sack props on Nick Bosa and Bryce Young’s passing-yard ladders headline the prop board; NFC West futures will swing if the Niners slip.
Bye week: Denver Broncos, Los Angeles Chargers, Miami Dolphins, Washington Commanders
NFL Week 12 Schedule & How To Watch
Thursday, November 20th, 2025
- Buffalo Bills at Houston Texans – 8:15 p.m. – Prime Video
Sunday, November 23rd, 2025
- New England Patriots at Cincinnati Bengals – 1:00 p.m. – CBS / Paramount+
- Pittsburgh Steelers at Chicago Bears – 1:00 p.m. – CBS / Paramount+
- Indianapolis Colts at Kansas City Chiefs – 1:00 p.m. – CBS / Paramount+
- New York Jets at Baltimore Ravens – 1:00 p.m. – CBS / Paramount+
- New York Giants at Detroit Lions – 1:00 p.m. – FOX / Fox Sports app
- Seattle Seahawks at Tennessee Titans – 1:00 p.m. – FOX / Fox Sports app
- Minnesota Vikings at Green Bay Packers – 1:00 p.m. – FOX / Fox Sports app
- Cleveland Browns at Las Vegas Raiders – 4:05 p.m. – CBS / Paramount+
- Jacksonville Jaguars at Arizona Cardinals – 4:05 p.m. – CBS / Paramount+
- Atlanta Falcons at New Orleans Saints – 4:25 p.m. – FOX / Fox Sports app
- Philadelphia Eagles at Dallas Cowboys – 4:25 p.m. – FOX / Fox Sports app
Sunday Night
- Tampa Bay Buccaneers at Los Angeles Rams – 8:20 p.m. – NBC / Peacock
Monday, November 24th, 2025
- Carolina Panthers at San Francisco 49ers – 8:15 p.m. – ESPN (MNF)
How to watch NFL Week 12 2025
Thursday Night Football: Exclusive on Prime Video. A Prime membership (or standalone TNF plan) is required.
Sunday Afternoon
- CBS games stream locally on Paramount+.
- FOX games stream free with a pay-TV login in the Fox Sports app (and are expected on the upcoming Fox One service).
- Sunday Night Football: Broadcast on NBC and streams nationwide on Peacock.
- Monday Night Football: Airs on ESPN; also available in the ESPN app for authenticated subscribers.
- Cord-cutting bundles: YouTube TV, Fubo, Hulu + Live TV, and DirecTV Stream carry CBS, FOX, NBC, and ESPN, ensuring access to every Week 12 telecast.
- NFL+: Offers live local and prime-time games on mobile, plus NFL RedZone for Sunday-afternoon whip-around coverage.
