Must-Watch Games — NFL Week 4 (2025) & Betting Angles
Thursday Night Football
Pittsburgh Steelers @ Cincinnati Bengals
Thu., Sept 25 — 8:15 p.m. ET | Prime Video
- Opening NFL odds make Cincinnati a short field-goal chalk on the point spread and a modest favorite on the moneyline, with the total parked in the mid-40s.
- Steelers backers who fear a late back-door cover can tease Pittsburgh up to +9 or grab a plus-money ML for bigger upside.
- Bengals bettors worried about laying juice might pivot to an alternate spread (–6.5) at a plus price or anchor Cincy’s ML in a weekend parlay.
- Look for juicy player-prop menus: Joe Burrow passing-yard “ladder” bets, T.J. Watt sack props, and anytime-TD odds on Ja’Marr Chase.
- The winner seizes an early AFC North tiebreaker and will see its division-title futures shorten by Monday morning.
London Game (Wembley Stadium)
Los Angeles Rams vs. Jacksonville Jaguars
Sun., Sept 28 — 9:30 a.m. ET | NFL Network
- Neutral-site NFL odds install Jacksonville as roughly a 4-point favorite with a total near 47.
- Early-riser bettors can tease the Jags down to a pick’em or grab the Rams +10 in a six-point teaser to combat Wembley variance.
- Trevor Lawrence “home-away-from-home” vibes should juice anytime-TD props on Calvin Ridley, while Rams believers can chase plus-money ML tied to the under in a same-game parlay.
- Remember the unique kickoff: live-betters may find soft totals if both offenses start sluggish after the trans-Atlantic trip.
- It’s L.A.’s first U.K. appearance since 2019, adding extra publicity — and wagering volume — to the breakfast-ball window.
Early Sunday Spotlight
Las Vegas Raiders @ Kansas City Chiefs
Sun., Sept 28 — 1:00 p.m. ET | CBS
- Consensus NFL odds open Kansas City as a double-digit chalk with a prohibitive ML and a total around 50.
- Chiefs supporters can shave juice by sliding K.C.’s ML into a multi-leg round-robin or targeting an alternate spread (–13.5) at plus money.
- Raiders bettors who like the upgraded pass rush can grab +10.5 or sprinkle the hefty underdog price; combine Vegas +10.5 with the under in a same-game parlay for an even bigger payout.
- Expect a flood of Travis Kelce and Davante Adams anytime-TD props, plus sack-total overs for Maxx Crosby.
- An upset would shake up AFC West futures and could dent Kansas City’s path to another No. 1 seed.
Early Sunday Spotlight
Philadelphia Eagles @ Minnesota Vikings
Sun., Sept 28 — 1:00 p.m. ET | FOX
- Opening NFL odds list Philadelphia a 3-point road favorite with a 49-point over/under.
- Eagles backers who hate the hook can buy down to –2.5 or pair Philly’s ML with the over in a same-game parlay built on shoot-out expectations.
- Vikings supporters can tease Minnesota up to +9 or chase a +130 ML if they trust J.J. McCarthy’s home debut magic.
- Justin Jefferson receiving-yard ladders and Jalen Hurts anytime-TD odds headline the prop board; laddering both in correlated parlays can deliver outsized returns.
- Because both clubs sit near the top of NFC futures, even small line moves here will ripple through conference-title markets.
NFL Week 4 Schedule & How To Watch
*All times Eastern
Here is the NFL Week 4 schedule for the 2025 season, including dates, times (ET), and how to watch each game.
This week features an international game in London and two Monday night matchups.
Note that the Baltimore Ravens and Buffalo Bills have a bye this week.
Thursday, September 25th,2025
- Pittsburgh Steelers at Cincinnati Bengals – 8:15 PM – Prime Video
Sunday, September 28th, 2025
- Los Angeles Rams vs. Jacksonville Jaguars (London, Wembley) – 9:30 AM – NFL Network
- New Orleans Saints at Chicago Bears – 1:00 PM – FOX
- Miami Dolphins at Cleveland Browns – 1:00 PM – CBS
- Las Vegas Raiders at Kansas City Chiefs – 1:00 PM – CBS
- Philadelphia Eagles at Minnesota Vikings – 1:00 PM – FOX
- Carolina Panthers at New York Jets – 1:00 PM – FOX
- New England Patriots at Tennessee Titans – 1:00 PM – CBS
- New York Giants at Denver Broncos – 4:05 PM – CBS
- Indianapolis Colts at Los Angeles Chargers – 4:05 PM – CBS
- Green Bay Packers at Arizona Cardinals – 4:25 PM – FOX
- Washington Commanders at Dallas Cowboys – 4:25 PM – FOX
- Atlanta Falcons at San Francisco 49ers – 8:20 PM – NBC
- Monday, Sept. 29 Tampa Bay Buccaneers at Detroit Lions – 7:00 PM – ESPN/ABC
- Houston Texans at Seattle Seahawks – 10:00 PM – ESPN+
Monday, September 29th, 2025
- Tampa Bay Buccaneers at Detroit Lions – 7:00 PM – ESPN/ABC
- Houston Texans at Seattle Seahawks – 10:00 PM – ESPN+
How to Watch NFL Week 4 (2025)
- Thursday Night Football: Prime Video
- London Game (Sunday morning): NFL Network
- Sunday Afternoon: CBS and FOX (regional coverage; check local listings)
- Sunday Night Football: NBC (also on Peacock)
- Monday Night Football: Early game on ESPN/ABC; late game on ESPN+
Streaming Options:
- Paramount+ streams CBS games
- Fox One streams FOX games
- Peacock streams NBC games
- NFL+ for mobile and out-of-market games
- Fubo, YouTube TV, Hulu + Live TV, and DirecTV Stream carry all major networks
Bet on NFL Week 4 odds with confidence at BetUS. We offer the most competitive odds, ensuring you have the best chance to maximize your returns.
So, whether you’re betting on spreads, moneylines, game totals, player props, or game props, we’ve got you covered. Jump into the excitement, place your bets, and enjoy every moment of NFL Week 4.
