Must-Watch Games — NFL Week 5 (2025) & Betting Angles
Thursday Night Football
San Francisco 49ers @ Los Angeles Rams
Thu., Oct 2 — 8:15 p.m. ET (Prime Video)
- Opening NFL odds install San Francisco as a short field-goal chalk (≈ –3) with a –160 moneyline and a 46-point over/under.
- Rams backers can buy a half-point to +3.5 or drop L.A. into a six-point teaser with another underdog for extra cushion.
- Niners bettors who dislike the juice might shift to an alternate spread (–6.5) at plus money or anchor the moneyline in a multi-leg parlay.
- Look for juicy player props: Christian McCaffrey “yardage ladders,” Deebo Samuel anytime-TD odds, and Aaron Donald sack props—all certain to boost the prime-time handle.
International Series (London)
Minnesota Vikings vs. Cleveland Browns (Tottenham Hotspur Stadium)
Sun., Oct 5 — 9:30 a.m. ET (NFL Network)
- Neutral-site NFL odds make Cleveland a modest 2.5-point favorite, while the total rests in the mid-40s.
- Vikings believers can snag the underdog moneyline or tease Minnesota up to +8.5 alongside the under for an overseas same-game parlay.
- Browns bettors may attack an alternate line (–5.5) at plus odds, banking on the league’s top pass rush to rattle rookie QB J.J. McCarthy.
- Early kickoffs often start sluggish—live-bet enthusiasts can hunt a middle if the total dips after a scoreless first quarter.
Late Sunday Window
Detroit Lions @ Cincinnati Bengals
Sun., Oct 5 — 4:25 p.m. ET (FOX)
- Consensus NFL odds list Cincinnati as a slim 1.5-point chalk with a 53-point total—Week 5’s highest number.
- Lions backers expecting a shoot-out can pair Detroit +1.5 with the over in a same-game parlay for a bigger return.
- Bengals bettors worried about the juice might pivot to an alternate spread (–4.5) at plus money, trusting Joe Burrow to win by more than a field goal.
- Expect “yardage ladder” markets on Jared Goff and Burrow, plus anytime-TD props on Amon-Ra St. Brown and Ja’Marr Chase to dominate the prop board.
Sunday Night Football
New England Patriots @ Buffalo Bills
Sun., Oct 5 — 8:20 p.m. ET (NBC/Peacock)
- Early NFL odds post Buffalo –6 with a –250 moneyline and a 48-point total.
- Patriots supporters can tease rookie Drake Maye up to +12 or sprinkle the +200 dog price for a statement upset.
- Bills backers who fear a back-door cover can move to an alternate spread (–9.5) at plus odds or fold Buffalo’s moneyline into a weekend round-robin.
- Look for Josh Allen rushing-TD props, Maye interception totals, and live-bet swings if Orchard Park winds kick up.
Monday Night Football
Kansas City Chiefs @ Jacksonville Jaguars
Mon., Oct 6 — 8:15 p.m. ET (ESPN)
- Prime-time NFL odds make Kansas City a 4-point road favorite (≈ –180 ML) with a 51-point over/under.
- Chiefs bettors chasing value may jump to an alternate spread (–6.5) for plus money or anchor K.C.’s ML in a two-leg teaser with the total over.
- Jaguars believers can grab +4 or tease Jacksonville up to +10; combining the dog spread with the under in a same-game parlay offers a juicy payout.
- Expect massive demand for Patrick Mahomes passing-TD props, Travis Kelce anytime-TD markets, and Trevor Lawrence yardage ladders—each capable of moving the prop lines before kickoff.
NFL Week 5 Schedule & How To Watch
Here is the NFL Week 5 schedule for the 2025 season, including dates, times (ET), and how to watch each game.
This week features an international game in London and 4 teams on their bye.
Thursday, October 2nd, 2025
San Francisco 49ers at Los Angeles Rams – 8:15 PM – Prime Video
Sunday, October 5th, 2025
- Minnesota Vikings vs. Cleveland Browns (London, Tottenham) – 9:30 AM – NFL Network
- New York Giants at New Orleans Saints – 1:00 PM – CBS / Paramount+
- Denver Broncos at Philadelphia Eagles – 1:00 PM – CBS / Paramount+
- Houston Texans at Baltimore Ravens – 1:00 PM – CBS / Paramount+
- Dallas Cowboys at New York Jets – 1:00 PM – Fox
- Las Vegas Raiders at Indianapolis Colts – 1:00 PM – Fox
- Miami Dolphins at Carolina Panthers – 1:00 PM – Fox
- Tennessee Titans at Arizona Cardinals – 4:05 PM – CBS / Paramount+
- Tampa Bay Buccaneers at Seattle Seahawks – 4:05 PM – CBS / Paramount+
- Washington Commanders at Los Angeles Chargers – 4:25 PM – Fox
- Detroit Lions at Cincinnati Bengals – 4:25 PM – Fox
- New England Patriots at Buffalo Bills – 8:20 PM – NBC / Peacock
Monday, October 6th, 2025
- Kansas City Chiefs at Jacksonville Jaguars – 8:15 PM – ESPN
Bye week: Atlanta Falcons, Chicago Bears, Green Bay Packers, and Pittsburgh Steelers.
How to Watch NFL Week 5 (2025)
- Thursday Night Football: Prime Video
- London Game (Sunday morning): NFL Network
Sunday Afternoon:
- CBS games stream on Paramount+
- FOX games are available on TV and Fox One (streaming)
- Sunday Night Football: NBC (also on Peacock)
- Monday Night Football: ESPN
- Streaming Bundles: Fubo, YouTube TV, Hulu + Live TV, and DirecTV Stream carry all major networks.
- NFL+: Mobile streaming and out-of-market games.
- NFL RedZone: Live look-ins and highlights during Sunday afternoon games.
Whether you’re betting on spreads, moneylines, game totals, player props, or game props, at BetUS, we’ve got you covered.
Jump into the excitement, place your bets, and enjoy every moment of NFL Week 5.
